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Mondal et al., 2020

Knockdown of SLC7A3 in mice or human hepatocytes reduces arginine transport, leading to decreased NO production and subsequent 3,5-Cyclic guanosine monophosphate synthesis

The molecule begins to unfold, exposing its hydrophobic core to water

Subsequently, the cells were harvested for RNA extraction (Cat# RC102-01, Vazyme Biotech Co., Ltd., China) to facilitate subsequent gene expression analysis